Marine Steroid Ca2: Potent Anti-HSV-1 Agent from Jellyfish
Marine Steroid Ca2: Potent Anti-HSV-1 Agent from Jellyfish
In-Vitro and In-Silico Anti-HSV-1 Activity of a Marine Steroid from the Jellyfish Cassiopea andromeda Venom
Tags: Universiti Malaya, Malaysia, Healthcare & Lifesciences, Science & Exploration
This study explores the anti-HSV-1 activity of a marine steroid extracted from the jellyfish Cassiopea andromeda venom. The extract and its purified compounds, Ca2 and Ca7, demonstrated strong antiviral effects in Vero cells, surpassing the efficacy of acyclovir. Computational docking revealed a high binding affinity of Ca2 to thymidine kinase, an enzyme crucial for HSV-1 replication. The jellyfish extract showed distinct chemical compositions, with several steroid structures. This marine-derived steroid holds potential for antiviral drug development.
IP Type or Form Factor: Discovery & Research; Material
TRL: 4 - minimum viable product built in lab
Industry or Tech Area: Biotechnology; Marine Exploration & Conservation
