MSBP Polymer: High-Resolution Cryo-EM Sample Preparation Aid
Metallo-Supramolecular Branched Polymer for Cryo-EM Sample Preparation
Tags: The University of Hong Kong, Hong Kong, Science & Exploration, Healthcare & Lifesciences
This technology introduces a metallo-supramolecular branched polymer (MSBP) that enhances the quality of Cryo-Electron Microscope (Cryo-EM) sample preparation by mitigating particle trapping at the air-water interface (AWI) and reducing preferred particle orientation. By improving particle distribution and protecting samples from AWI, MSBP increases resolution and map quality in Cryo-EM studies without requiring hardware modifications. Applications include structural biology and advanced imaging research, where precise particle behavior in vitreous ice is critical. The technology is protected by a submitted patent application, enabling the development of reagent kits for Cryo-EM sample preparation. It addresses a significant bottleneck in Cryo-EM, making sample preparation simpler and more reliable.
IP Type or Form Factor: Patent Pending; Material; Process & Method
TRL: 3 - proof of concept with needs validated
Industry or Tech Area: Nanotechnology; Biotechnology
