RNA Editing Targets circRNA C190 for New Lung Cancer Therapy
RNA Editing Targets circRNA C190 for New Lung Cancer Therapy
Oncogenicity of Circular RNA by Applying Gene-editing Technology
Tags: National Yang Ming Chiao Tung University, Taiwan, Healthcare & Lifesciences
Researchers from TVGH and NYCU have used CRISPR/Cas13a RNA editing technology to remove oncogenic circular RNA (circRNA C190), showing its potential to inhibit lung cancer cell growth. The team confirmed that circRNA C190 plays a critical role in transmitting cancer cell signals and can serve as a marker for non-invasive cancer diagnosis. Their study demonstrated that targeting C190 reduced cancer cell differentiation, migration, and growth. Applications include developing new treatments for non-small cell lung cancer using gene editing techniques. This innovation opens up novel pathways for cancer therapy beyond traditional EGFR-targeted drugs.
IP Type or Form Factor: Discovery & Research; Platform
TRL: 3 - proof of concept with needs validated
Industry or Tech Area: Biotechnology; Pharmaceutical Engineering
