Targeted Fat Secretion Control for Metabolic Diseases
Controlling Fat Secretion from the Liver
Tags: IIT Bombay, India, Healthcare & Lifesciences, Science & Exploration
Researchers have identified a novel mechanism involving the nanoscale motor protein Kinesin-1 that regulates the secretion of fat from the liver into the bloodstream by repackaging it into VLDL particles. They have developed a peptide that blocks this pathway, demonstrating its efficacy in cell culture and rat models, with potential applications in treating chronic dyslipidemia, fatty liver, obesity, and related conditions. Future steps include finding higher affinity peptides, peptidomimetic drugs, and exploring targeted gene delivery methods. This discovery provides a first-of-its-kind, selective intervention for fat secretion control and offers a new therapeutic avenue for metabolic diseases. The team seeks collaboration with pharmaceutical industries to advance drug formulation and delivery solutions for clinical applications.
IP Type or Form Factor: Discovery & Research; Process & Method
TRL: 4 - minimum viable product built in lab
Industry or Tech Area: Pharmaceutical Engineering; Nanotechnology
